A convenient synthesis of N-(hetero)arylamides by the oxidative coupling of methylheteroarenes with amines

Anjali Jaiswal; Preeti; Krishna Nand Singh

doi:10.1039/d2ob01106a

A convenient synthesis of N-(hetero)arylamides by the oxidative coupling of methylheteroarenes with amines

Org Biomol Chem. 2022 Aug 31;20(34):6915-6922. doi: 10.1039/d2ob01106a.

Authors

Anjali Jaiswal¹, Preeti¹, Krishna Nand Singh¹

Affiliation

¹ Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India. knsingh@bhu.ac.in.

PMID: 35979753
DOI: 10.1039/d2ob01106a

Abstract

An oxidative amidation of 2-methylpyridines/2-methylbenzimidazole with amines using copper acetate and elemental sulfur in DMSO to afford various N-(hetero)arylamides has been accomplished. Mechanistic studies reveal the intermediacy of N-(pyridin-2-ylmethyl)aniline and confirm the role of DMSO as the oxygen source.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines*
Catalysis
Copper
Dimethyl Sulfoxide*
Oxidative Coupling

Substances

Amines
Copper
Dimethyl Sulfoxide