Phenolic constituents with anti-inflammatory and cytotoxic activities from the rhizomes of Iris domestica

Phytochemistry. 2022 Nov:203:113370. doi: 10.1016/j.phytochem.2022.113370. Epub 2022 Aug 14.

Abstract

Four undescribed flavonoid glucosides (iridins B-C, tectoridin A and ampelopsinin A); one undescribed phenolic glucoside (diplostephioside B); one undescribed phenolic compound (phenanthrenetriol A); and seventeen known compounds were isolated from the rhizomes of Iris domestica. The chemical structures of the undescribed compounds were established by spectroscopic/spectrometric data interpretation using HRESIMS, NMR, and ECD. Tectoridin A, nigricin A and naringenin exhibited anti-inflammatory activities with inhibition rates of 53.71%, 57.68% and 88.71%, respectively, against the NF-κB signaling pathway at a concentration of 10 μM. 4'-O-methylnyasol (10 μM) exhibited 84.91% antiproliferative activity against the K562 human leukemia cell line with an IC50 value of 4.20 μM.

Keywords: Anti-inflammatory activity; Cytotoxic activity; Iridaceae; Iris domestica; Phenolic constituents.

MeSH terms

  • Anti-Inflammatory Agents / pharmacology
  • Antineoplastic Agents* / pharmacology
  • Flavonoids / analysis
  • Glucosides / chemistry
  • Humans
  • Iris Plant* / chemistry
  • Molecular Structure
  • NF-kappa B
  • Phenols
  • Rhizome / chemistry

Substances

  • 4'-O-methylnyasol
  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Flavonoids
  • Glucosides
  • NF-kappa B
  • Phenols