DNA double-strand break repair and nucleic acid-related immunity

Acta Biochim Biophys Sin (Shanghai). 2022 May 25;54(6):828-835. doi: 10.3724/abbs.2022061.

Abstract

DNA damage repair and innate immunity are two conserved mechanisms that both function in cellular stress responses. Recently, an increasing amount of evidence has uncovered the close relationship between these two ancient biological processes. Here, we review the classical function of factors involved in DNA repair, and especially double-strand break repair, in innate immunity; more importantly, we discuss the novel roles of DNA repair factors in regulating innate immunity and vice versa. In addition, we also review the roles of DNA repair, innate immunity and their crosstalk in human diseases, which suggest that these two pathways may be compelling targets for disease prevention and treatment.

Keywords: double-strand break repair; human disease; innate immune; nucleic acid sensor.

Publication types

  • Review

MeSH terms

  • DNA / genetics
  • DNA Breaks, Double-Stranded
  • DNA Damage
  • DNA Repair
  • Humans
  • Nucleic Acids*

Substances

  • Nucleic Acids
  • DNA

Grants and funding

The work was supported by the grants from the Chinese National Program on the Key Basic Research Project (No. 2018YFC2000100 to Z.M.), the National Natural Science Foundation of China (Nos. 81972457 to Y.J. , 31871438 to Z.M, and 82071565 to Z.M. and No. 82101634 to H.Z.), the “Shu Guang” Project supported by the Shanghai Municipal Education Commission and Shanghai Education Development Foundation (No. 19SG18 to Z.M.), the Program of the Shanghai Academic Research Leader (No. 19XD1403000 to Z.M.), and the Shanghai Sailing Program (No. 21YF1435900 to H.Z. and 22YF1434300 to Y.C.)