Lanthanide Ion Resonance-Driven Rayleigh Scattering of Nanoparticles for Dual-Modality Interferometric Scattering Microscopy

Lei Ding; Xuchen Shan; Dejiang Wang; Baolei Liu; Ziqing Du; Xiangjun Di; Chaohao Chen; Mahnaz Maddahfar; Ling Zhang; Yuzhi Shi; Peter Reece; Benjamin Halkon; Igor Aharonovich; Xiaoxue Xu; Fan Wang

doi:10.1002/advs.202203354

Lanthanide Ion Resonance-Driven Rayleigh Scattering of Nanoparticles for Dual-Modality Interferometric Scattering Microscopy

Adv Sci (Weinh). 2022 Nov;9(32):e2203354. doi: 10.1002/advs.202203354. Epub 2022 Aug 17.

Authors

Lei Ding^{1

2}, Xuchen Shan^{1

2

3}, Dejiang Wang¹, Baolei Liu³, Ziqing Du¹, Xiangjun Di¹, Chaohao Chen², Mahnaz Maddahfar¹, Ling Zhang², Yuzhi Shi⁴, Peter Reece⁵, Benjamin Halkon⁶, Igor Aharonovich^{1

7}, Xiaoxue Xu⁸, Fan Wang^{2

3}

Affiliations

¹ School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.
² School of Electrical and Data Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.
³ School of Physics, Beihang University, Beijing, 100191, China.
⁴ National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Department of Micro/Nano Electronics, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
⁵ School of Physics, The University of New South Wales, Kensington, New South Wales, 2033, Australia.
⁶ Centre for Audio, Acoustics & Vibration, Faculty of Engineering & IT, University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.
⁷ ARC Centre of Excellence for Transformative Meta-Optical Systems (TMOS), Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.
⁸ School of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.

Abstract

Light scattering from nanoparticles is significant in nanoscale imaging, photon confinement. and biosensing. However, engineering the scattering spectrum, traditionally by modifying the geometric feature of particles, requires synthesis and fabrication with nanometre accuracy. Here it is reported that doping lanthanide ions can engineer the scattering properties of low-refractive-index nanoparticles. When the excitation wavelength matches the ion resonance frequency of lanthanide ions, the polarizability and the resulted scattering cross-section of nanoparticles are dramatically enhanced. It is demonstrated that these purposely engineered nanoparticles can be used for interferometric scattering (iSCAT) microscopy. Conceptually, a dual-modality iSCAT microscopy is further developed to identify different nanoparticle types in living HeLa cells. The work provides insight into engineering the scattering features by doping elements in nanomaterials, further inspiring exploration of the geometry-independent scattering modulation strategy.

Keywords: interferometric scattering microscopy; lanthanide-doped nanoparticle; resonance; scattering.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

HeLa Cells
Humans
Ions
Lanthanoid Series Elements*
Microscopy
Nanoparticles*

Substances

Lanthanoid Series Elements
Ions

Abstract

Publication types

MeSH terms

Substances

Grants and funding