Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor

Carolina Emerick; Fernanda Viviane Mariano; Pablo Agustin Vargas; Jacques E Nör; Cristiane H Squarize; Rogerio M Castilho

doi:10.1016/j.critrevonc.2022.103792

Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor

Crit Rev Oncol Hematol. 2022 Nov:179:103792. doi: 10.1016/j.critrevonc.2022.103792. Epub 2022 Aug 13.

Authors

Carolina Emerick¹, Fernanda Viviane Mariano², Pablo Agustin Vargas³, Jacques E Nör⁴, Cristiane H Squarize⁵, Rogerio M Castilho⁶

Affiliations

¹ Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil; Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil; Department of Periodontics and Oral Medicine, Laboratory of Epithelial Biology, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
² Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
³ Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
⁴ Department of Cariology, Restorative Sciences, and Endodontics, Angiogenesis Research Laboratory, University of Michigan School of Dentistry, Ann Arbor, MI, USA; Department of Otolaryngology-Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
⁵ Department of Periodontics and Oral Medicine, Laboratory of Epithelial Biology, University of Michigan School of Dentistry, Ann Arbor, MI, USA; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
⁶ Department of Periodontics and Oral Medicine, Laboratory of Epithelial Biology, University of Michigan School of Dentistry, Ann Arbor, MI, USA; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. Electronic address: rcastilh@umich.edu.

PMID: 35973662
DOI: 10.1016/j.critrevonc.2022.103792

Abstract

Adenoid cystic carcinoma (ACC) is a biphasic malignant lesion that can develop at various anatomical sites. Salivary and lacrimal ACC lesions have a high risk of local invasion, metastasis, and poor prognosis. In more distant organs, such as the breast, ACC is a rarer and less aggressive lesion. One of the major predictors of mortality of ACC is perineural invasion, which can be seen in 30 % of breast lesions, 85% of salivary lesions, and almost 100 % of lacrimal gland tumors. The biological differences between these three ACC tumors are still poorly understood. We focused on the current understanding of the genetic variations observed on ACC tumors and prognostic differences associated with distinct anatomical sites. A special effort was made to present the currently available therapies alongside the emerging strategies under development.

Keywords: Adenoid Cystic Carcinoma; Breast; Cancer prognosis; Lacrimal gland; Salivary gland.

Publication types

Review

MeSH terms

Carcinoma, Adenoid Cystic* / diagnosis
Carcinoma, Adenoid Cystic* / genetics
Carcinoma, Adenoid Cystic* / therapy
Eye Neoplasms* / diagnosis
Eye Neoplasms* / pathology
Eye Neoplasms* / therapy
Humans
Lacrimal Apparatus Diseases* / diagnosis
Lacrimal Apparatus Diseases* / genetics
Lacrimal Apparatus Diseases* / therapy
Lacrimal Apparatus* / pathology
Salivary Gland Neoplasms* / diagnosis
Salivary Gland Neoplasms* / genetics
Salivary Gland Neoplasms* / therapy