A review of study designs and data analyses in metabolomics studies in myopia

Xiao-Wen Hou; Ying Wang; Qian Wu; Chaofu Ke; Chen-Wei Pan

doi:10.1016/j.ab.2022.114850

A review of study designs and data analyses in metabolomics studies in myopia

Anal Biochem. 2022 Oct 15:655:114850. doi: 10.1016/j.ab.2022.114850. Epub 2022 Aug 13.

Authors

Xiao-Wen Hou¹, Ying Wang¹, Qian Wu¹, Chaofu Ke¹, Chen-Wei Pan²

Affiliations

¹ School of Public Health, Medical College of Soochow University, Suzhou, China.
² School of Public Health, Medical College of Soochow University, Suzhou, China. Electronic address: pcwonly@gmail.com.

PMID: 35970413
DOI: 10.1016/j.ab.2022.114850

Abstract

Metabolomics analyzes the entire range of small molecule metabolites in biological systems to reveal the response signals that are transmitted from "genetics and environment", which could help us understand complex phenotypes of diseases. Metabolomics has been successfully applied to the study of eye diseases including age-related macular degeneration, glaucoma, and diabetic retinopathy. In this review, we summarize the findings of myopic metabolomics and discuss them from a design and analysis perspective. Finally, we provide new ideas for the future development of myopia metabolomics research based on the broader ocular metabolomics study.

Keywords: Metabolites; Metabolomics; Metabolomics technology; Myopia.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Data Analysis*
Humans
Metabolomics
Myopia*