Bioactive constituents from the leaves of Lonicera japonica

Jinqian Yu; Kai Wang; Hengqiang Zhao; Long Chen; Xiao Wang

doi:10.1016/j.fitote.2022.105277

Bioactive constituents from the leaves of Lonicera japonica

Fitoterapia. 2022 Oct:162:105277. doi: 10.1016/j.fitote.2022.105277. Epub 2022 Aug 12.

Authors

Jinqian Yu¹, Kai Wang², Hengqiang Zhao², Long Chen², Xiao Wang³

Affiliations

¹ Key Laboratory for Applied Techonology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China; School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China. Electronic address: yujinqian87528@126.com.
² Key Laboratory for Applied Techonology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China; School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China.
³ Key Laboratory for Applied Techonology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China; School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China. Electronic address: wangx@sdas.org.

PMID: 35970409
DOI: 10.1016/j.fitote.2022.105277

Abstract

Six new isolates including three new alkaloids (1-3), one new secoiridoid glycoside (4) and one new 11-delactonization-secoiridoid glycoside (5), and one new organic acid (6) were identified from the leaves of Lonicera japonica, among which 1 and 2 assigned as a pair of configurational isomers possessed two oxazolidin-2-one fragments connected through NN bond. The structures were elucidated by the NMR data and ICD analysis. All the compounds (1-6) were tested for their antioxidant and hepatoprotective activities using cell models of ABAP-induced HepG₂ cell and APAP-induced HepG₂ cell by the MTT method. Outstandingly, compound 2 exhibited remarkable antioxidative activity with inhibitory rate of 117.2%, and compounds 2, 4, 6 exhibited significant effects with inhibitory rates of 68.1%, 69.3%, 69.2%, respectively.

Keywords: 11-delactonization-secoiridoid glycoside; Alkaloid; Antioxidant activity; Hepatoprotective activity; Leaves of Lonicera japonica.

MeSH terms

Acetaminophen
Alkaloids* / chemistry
Antioxidants
Iridoid Glycosides
Lonicera* / chemistry
Molecular Structure
Oxazolidinones* / analysis
Plant Leaves / chemistry

Substances

Alkaloids
Antioxidants
Iridoid Glycosides
Oxazolidinones
Acetaminophen