The evidence from many studies shows that antifoulants (Cu2O) and organic antifouling agents with broad-spectrum characteristics in antifouling coatings cause varying degrees of damage to the environment. Therefore, this study prepared Cu2O-free self-polishing antifouling coatings based on amide derivatives inspired by capsaicin (ADIC-CSAC) with green and environmentally friendly characteristics. First, the structure of ADIC and the composition of ADIC-CSAC were characterized by IR, 1H NMR, 13C NMR, HRMS, and EDX. Moreover, antibacterial, anti-algal, static raft tests and changes in the mass loss, roughness, contact angle, and surface energy were used to evaluate the antifouling and self-polishing properties of ADIC-CSAC. The test results showed that ADIC and ADIC-CSAC were successfully prepared and ADIC-CSAC possessed good antifouling and self-polishing properties. ADIC-CSAC exhibited antibacterial and anti-algal rates of over 88 and 72%, respectively, and was found to have satisfactory antifouling properties over 9 months in a real marine field. Overall, the prepared ADIC-CSAC possesses good and green antifouling and self-polishing properties, which lays a foundation for research on green antifouling coatings used for environmental protection.