Malignant juxtaglomerular cell tumor

Daniel Geisler; Fawaz Almutairi; Ivy John; Gabriela Quiroga-Garza; Michelle Yu; Raja Seethala; Sheldon Bastacky

doi:10.1016/j.eucr.2022.102176

Malignant juxtaglomerular cell tumor

Urol Case Rep. 2022 Jul 31:45:102176. doi: 10.1016/j.eucr.2022.102176. eCollection 2022 Nov.

Authors

Daniel Geisler¹, Fawaz Almutairi¹, Ivy John¹, Gabriela Quiroga-Garza¹, Michelle Yu², Raja Seethala¹, Sheldon Bastacky¹

Affiliations

¹ Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
² Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Abstract

Juxtaglomerular cell tumors (JGCTs) are rare, typically benign neoplasms; only rare cases are clinically or histologically malignant. We herein report the histologic, immunophenotypic, and molecular features of a clinically unsuspected, diagnostically challenging case of malignant JGCT in a 23-year-old man. The diagnosis is confirmed with electron microscopy. The case is notable for its marked mitotic activity, which has not been previously reported in JGCTs, and novel finding of GATA3 immunohistochemical positivity.

Keywords: GATA3; Juxtaglomerular cell tumor; Kidney; Malignant; Renin.

Publication types

Case Reports