Mantle cell lymphoma with aseptic meningitis mimicking hydrocephalus on brain imaging

Nagoya J Med Sci. 2022 May;84(2):470-476. doi: 10.18999/nagjms.84.2.470.

Abstract

An 83-year-old man underwent head computed tomography (CT) to investigate cognitive decline and gait disturbance and was admitted to undergo a cerebrospinal fluid (CSF) tap test for suspected idiopathic normal-pressure hydrocephalus. He had a history of chemotherapy for mantle cell lymphoma (MCL), but CT on admission showed no evidence of recurrence. After admission, his level of consciousness rapidly deteriorated and CSF examination suggested infiltration of MCL into the central nervous system (CNS). Although CNS involvement in MCL is rare, this case demonstrates that even if recurrence of MCL is not suspected based on CT findings.

Keywords: aseptic meningitis; dementia; hydrocephalus; mantle cell lymphoma; meningeal infiltration.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged, 80 and over
  • Brain / diagnostic imaging
  • Brain / pathology
  • Humans
  • Hydrocephalus*
  • Lymphoma, Mantle-Cell* / diagnostic imaging
  • Lymphoma, Mantle-Cell* / drug therapy
  • Male
  • Meningitis, Aseptic* / diagnostic imaging
  • Neuroimaging