Insights into the roles of bacterial infection and antibiotics in Parkinson's disease

Shuo Sheng; Shuo Zhao; Feng Zhang

doi:10.3389/fcimb.2022.939085

Insights into the roles of bacterial infection and antibiotics in Parkinson's disease

Front Cell Infect Microbiol. 2022 Jul 28:12:939085. doi: 10.3389/fcimb.2022.939085. eCollection 2022.

Authors

Shuo Sheng^{1

2

3}, Shuo Zhao⁴, Feng Zhang^{1

2

3

5}

Affiliations

¹ Key Laboratory of Basic Pharmacology of the Ministry of Education, Zunyi Medical University, Zunyi, China.
² Joint International Research Laboratory of Ethnomedicine of the Ministry of Education, Zunyi Medical University, Zunyi, China.
³ Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical University, Zunyi, China.
⁴ Electron Microscopy Room of School of Basic Medicine, Zunyi Medical University, Zunyi, China.
⁵ Laboratory Animal Center, Zunyi Medical University, Zunyi, China.

Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which is accompanied with the classical motor symptoms and a range of non-motor symptoms. Bacterial infection affects the neuroinflammation associated with the pathology of PD and various antibiotics have also been confirmed to play an important role not only in bacterial infection, but also in the PD progression. This mini-review summarized the role of common bacterial infection in PD and introduced several antibiotics that had anti-PD effects.

Keywords: Parkinson’s disease; anti-PD; antibiotics; bacterial infection; neuroinflammation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Bacterial Infections* / complications
Bacterial Infections* / drug therapy
Humans
Parkinson Disease* / complications
Parkinson Disease* / drug therapy

Substances

Anti-Bacterial Agents