Pathophysiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap

Andi Hudler; Fernando Holguin; Sunita Sharma

doi:10.1016/j.iac.2022.04.008

Pathophysiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap

Immunol Allergy Clin North Am. 2022 Aug;42(3):521-532. doi: 10.1016/j.iac.2022.04.008. Epub 2022 Jun 30.

Authors

Andi Hudler¹, Fernando Holguin², Sunita Sharma¹

Affiliations

¹ Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, 9C03, Aurora, CO 80045, USA.
² Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, 9C03, Aurora, CO 80045, USA. Electronic address: Fernando.Holguin@cuanschutz.edu.

Abstract

Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a condition in which a person has clinical and biological features of both asthma and COPD. The pathophysiology behind the development of ACO is complex, with various inflammatory cells, cytokines, environmental factors, and architectural changes within the airways, all affecting a patient's clinical manifestation. A better understanding of the pathophysiologic mechanisms resulting in the development of ACO will help us to better identify potential drug targets and improve symptom burden and overall quality of life for patients living with ACO.

Keywords: Asthma; Asthma-COPD overlap; COPD; Pathophysiology.

Publication types

Review

MeSH terms

Asthma* / diagnosis
Humans
Pulmonary Disease, Chronic Obstructive* / diagnosis
Quality of Life

Abstract

Publication types

MeSH terms

Grants and funding