Attacking a DEAD problem: The role of DEAD-box ATPases in ribosome assembly and beyond

Methods Enzymol. 2022:673:19-38. doi: 10.1016/bs.mie.2022.03.033. Epub 2022 Apr 9.

Abstract

DEAD-box proteins are a subfamily of ATPases with similarity to RecA-type helicases that are involved in all aspects of RNA Biology. Despite their potential to regulate these processes via their RNA-dependent ATPase activity, their roles remain poorly characterized. Here I describe a roadmap to study these proteins in the context of ribosome assembly, the process that utilizes more than half of all DEAD-box proteins encoded in the yeast genome.

Keywords: DEAD box protein roles; Dbp5; Dbp7; Has1; Prp5; Prpr28; Rok1; Sub2.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases* / metabolism
  • DEAD-box RNA Helicases / genetics
  • DEAD-box RNA Helicases / metabolism
  • RNA / metabolism
  • Ribosomes / metabolism
  • Saccharomyces cerevisiae* / genetics
  • Saccharomyces cerevisiae* / metabolism

Substances

  • RNA
  • Adenosine Triphosphatases
  • DEAD-box RNA Helicases