Development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus A71 and coxsackievirus A16

Virol Sin. 2022 Oct;37(5):769-773. doi: 10.1016/j.virs.2022.08.001. Epub 2022 Aug 11.

Abstract

  1. •

    A stable EV-A71 virus vector was created to generate chimeric strains expressing capsid protein genes of EV-A71 C5 and CA16.

  2. •

    Phenotypic and genetic stability of the generated chimeric EV-A71 and CA16 were analyzed.

  3. •

    The amino acids at the cleavage site between VP1 and 2A is crucial for stability.

Publication types

  • Letter

MeSH terms

  • Antigens, Viral
  • Enterovirus A, Human* / genetics
  • Enterovirus Infections*
  • Enterovirus* / genetics
  • Hand, Foot and Mouth Disease*
  • Humans
  • Temperature

Substances

  • Antigens, Viral