Transfer RNA-derived small RNAs (tsRNAs): Versatile regulators in cancer

Dandan Xu; Deqian Qiao; Yunlong Lei; Chundong Zhang; Youquan Bu; Ying Zhang

doi:10.1016/j.canlet.2022.215842

Transfer RNA-derived small RNAs (tsRNAs): Versatile regulators in cancer

Cancer Lett. 2022 Oct 10:546:215842. doi: 10.1016/j.canlet.2022.215842. Epub 2022 Aug 11.

Authors

Dandan Xu¹, Deqian Qiao¹, Yunlong Lei¹, Chundong Zhang¹, Youquan Bu², Ying Zhang³

Affiliations

¹ Department of Biochemistry and Molecular Biology, School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China.
² Department of Biochemistry and Molecular Biology, School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China. Electronic address: buyqcn@cqmu.edu.cn.
³ Department of Biochemistry and Molecular Biology, School of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China. Electronic address: zhangying@cqmu.edu.cn.

PMID: 35964819
DOI: 10.1016/j.canlet.2022.215842

Abstract

tRNA-derived small RNAs (tsRNAs) represent a novel class of regulatory small non-coding RNAs (sncRNAs), produced by the specific cleavage of transfer RNAs (tRNAs). In recent years, pilot studies one after the other have uncovered the critical roles of tsRNAs in various fundamental biological processes as well as in the development of human diseases including cancer. Based on the newly updated hallmarks of cancer, we provide a comprehensive review regarding the dysregulation, functional implications and complicated molecular mechanisms of tsRNAs in cancer. In addition, the potential technical challenges and future prospects in the fields of tsRNA research are discussed in this review.

Keywords: Non-coding RNA; sncRNA; tRNA; tsRNA.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Neoplasms*
RNA, Small Untranslated*
RNA, Transfer

Substances

RNA, Small Untranslated
RNA, Transfer