Emerging biosensors to detect aflatoxin M1 in milk and dairy products

Qi Chen; Meng Meng; Wang Li; Ying Xiong; Yong Fang; Qinlu Lin

doi:10.1016/j.foodchem.2022.133848

Emerging biosensors to detect aflatoxin M₁ in milk and dairy products

Food Chem. 2023 Jan 1:398:133848. doi: 10.1016/j.foodchem.2022.133848. Epub 2022 Aug 3.

Authors

Qi Chen¹, Meng Meng², Wang Li², Ying Xiong³, Yong Fang⁴, Qinlu Lin²

Affiliations

¹ Institute of Translational Medicine, Nanchang University, Nanchang 330031, China; College of Food Science and Engineering, Hainan University, Haikou 570228, China.
² National Engineering Research Center of Rice and Byproducts Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
³ National Engineering Research Center of Rice and Byproducts Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China. Electronic address: yingxiong201468@163.com.
⁴ College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China.

PMID: 35964572
DOI: 10.1016/j.foodchem.2022.133848

Abstract

Aflatoxin M₁ (AFM₁) is an important risk factor threatening the safety of milk and dairy products due to its carcinogenic and teratogenic effects on humans. To prevent AFM₁ from causing damage to human health, developing reliable methods to monitor its levels in milk and dairy products is of great importance. Biosensors built with recognition and detection systems have attracted extensive attention for their simplicity, portability, sensitivity, and selectivity. The commonly developed biosensors for detecting AFM₁ are antibody-based sensors (immunosensors) and aptamer-based sensors (aptasensors). This review focused on the advances of immunosensors, aptasensors, and other emerging receptors-based sensors for the detection of AFM₁ in milk and dairy products in the past five years. These biosensors were reviewed with representative examples according to their signal transduction systems, mainly including colorimetry, fluorescence, electrochemistry, and others. The unique advantages and drawbacks of immunosensor and aptasensor, and the future opportunities and challenges were also discussed.

Keywords: Aflatoxin M(1); Aptasensor; Dairy products; Immunosensor; Milk.

Publication types

Review

MeSH terms

Aflatoxin M1* / analysis
Animals
Biosensing Techniques* / methods
Dairy Products / analysis
Electrochemistry
Food Contamination / analysis
Humans
Immunoassay
Milk / chemistry

Substances

Aflatoxin M1