Conversion of proteins into DNA mimetics by lipid peroxidation

Abstract

Conversion of primary amino groups to pyrrole derivatives occurs by modifying lysine residues of proteins with lipid peroxidation products. Pyrrolated proteins exhibit electronegativity and electronic properties and are recognized by DNA-binding molecules, such as anti-DNA autoantibodies and DNA intercalators. This review summarizes the state of knowledge about the chemistry of this unique conversion reaction of proteins into DNA mimetics by lipid peroxidation.

Keywords: Anti-DNA autoantibodies; DNA mimic Proteins; Lipid peroxidation; Protein N-Pyrrolation; γ-ketoaldehydes.