A robust [11C]acetate synthesis on a TRACERLab FX C pro module

Jan Wenz; Felix Arndt; Samuel Samnick

doi:10.1016/j.apradiso.2022.110356

A robust [¹¹C]acetate synthesis on a TRACERLab FX C pro module

Appl Radiat Isot. 2022 Oct:188:110356. doi: 10.1016/j.apradiso.2022.110356. Epub 2022 Jul 8.

Authors

Jan Wenz¹, Felix Arndt², Samuel Samnick²

Affiliations

¹ Interdisciplinary PET Center, Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Strasse 6, 97080, Würzburg, Germany. Electronic address: Wenz_J@ukw.de.
² Interdisciplinary PET Center, Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Strasse 6, 97080, Würzburg, Germany.

PMID: 35964418
DOI: 10.1016/j.apradiso.2022.110356

Abstract

Carbon-11 labelled acetate ([¹¹C]acetate) is a radiotracer of importance in clinical practice as well as in preclinical research. The TRACERLab FX C Pro Synthesizer can be used this sensitive carboxylation reaction. Starting from 11 GBq [¹¹C]CO₂, we were able to isolate about 3 GBq [¹¹C]acetate after only 20 min reaction time (yield 56 ± 7%, n = 10).

Keywords: Carboxylation; Positron emission tomography; TRACERLab FX C Pro; [(11)C]acetate.

MeSH terms

Acetates
Positron-Emission Tomography* / methods
Radiopharmaceuticals*

Substances

Acetates
Radiopharmaceuticals