New and Emerging Therapies for Dyslipidemia

Endocrinol Metab Clin North Am. 2022 Sep;51(3):635-653. doi: 10.1016/j.ecl.2022.02.004. Epub 2022 Jul 10.

Abstract

Atherosclerotic cardiovascular disease (ASCVD) continues to represent a growing global health challenge. Despite guideline-recommended treatment of ASCVD risk, including antihypertensive, high-intensity statin therapy, and antiaggregant agents, high-risk patients, especially those with established ASCVD and patients with type 2 diabetes, continue to experience cardiovascular events. Recent years have brought significant developments in lipid and atherosclerosis research. Several lipid drugs owe their existence, in part, to human genetic evidence. Here, the authors briefly review the mechanisms, the effect on lipid parameters, and safety profiles of some of the most promising new lipid-lowering approaches that will be soon available in our daily clinical practice.

Keywords: ANGPTL3; Angiopoietin-like protein 3; Atherosclerotic cardiovascular disease (ASCVD); Inclisiran; SPPARM; Selective PPAR alpha modulators; SiRNA; Volanesorsen.

Publication types

  • Review

MeSH terms

  • Atherosclerosis* / drug therapy
  • Atherosclerosis* / etiology
  • Diabetes Mellitus, Type 2* / complications
  • Diabetes Mellitus, Type 2* / drug therapy
  • Dyslipidemias* / drug therapy
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors* / therapeutic use
  • Lipids

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Lipids