The prevalence of sexual dysfunction and erectile dysfunction in men with multiple sclerosis: A systematic review and meta-analysis

V Shaygannejad; O Mirmosayyeb; S Vaheb; N Nehzat; M Ghajarzadeh

doi:10.1016/j.nrleng.2022.08.002

The prevalence of sexual dysfunction and erectile dysfunction in men with multiple sclerosis: A systematic review and meta-analysis

Neurologia (Engl Ed). 2022 Aug 10:S2173-5808(22)00088-8. doi: 10.1016/j.nrleng.2022.08.002. Online ahead of print.

Authors

V Shaygannejad¹, O Mirmosayyeb², S Vaheb³, N Nehzat³, M Ghajarzadeh⁴

Affiliations

¹ Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
² Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran.
³ Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
⁴ Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran. Electronic address: m.ghajarzadeh@gmail.com.

PMID: 35963537
DOI: 10.1016/j.nrleng.2022.08.002

Abstract

Background: The prevalence of sexual dysfunction (SD) in men with multiple sclerosis (MS) is reported variously in different studies. The most common form of SD in these patients is erectile dysfunction (ED). The goal of this systematic review and meta-analysis is to determine the pooled prevalence of SD and ED in men suffering from MS.

Methods: We searched PubMed, Scopus, EMBASE, CINAHL, Web of Science, and gray literature (references of references, and congress abstracts) up to 14th November 2020.

Results: We found 3163 studies by primary search, 2246 were included after deletion of duplicates. Finally, 29 studies were included for meta-analysis. A total of 3349 patients were evaluated. The pooled prevalence of SD was 66% (95% CI: 64%-69%). The pooled prevalence of erectile dysfunction was 49% (95% CI: 47%-50%).

Conclusion: Sexual dysfunction is a prevalent complication of MS in male patients which should be considered by clinicians.

Keywords: Disfunción eréctil; Disfunción sexual; Erectile dysfunction; Esclerosis múltiple; Multiple sclerosis; Sexual dysfunction.