A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3-WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

Erwin A van Vliet; Riikka Immonen; Ofer Prager; Alon Friedman; Jens P Bankstahl; David K Wright; Terence J O'Brien; Heidrun Potschka; Olli Gröhn; Neil G Harris

doi:10.1002/epi4.12643

A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3-WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open. 2022 Aug 13. doi: 10.1002/epi4.12643. Online ahead of print.

Authors

Erwin A van Vliet^{1

2}, Riikka Immonen³, Ofer Prager⁴, Alon Friedman^{4

5}, Jens P Bankstahl⁶, David K Wright⁷, Terence J O'Brien⁸, Heidrun Potschka⁹, Olli Gröhn³, Neil G Harris^{10

11}

Affiliations

¹ Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.
² Amsterdam UMC Location University of Amsterdam, Department of (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam, The Netherlands.
³ A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
⁴ Departments of Physiology and Cell Biology, Cognitive and Brain Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
⁵ Department of Medical Neuroscience and Brain Repair Center, Dalhousie University, Halifax, Nova Scotia, Canada.
⁶ Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
⁷ Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
⁸ The Royal Melbourne Hospital, The University of Melbourne, The Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
⁹ Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University, Munich, Germany.
¹⁰ Department of Neurosurgery UCLA, UCLA Brain Injury Research Center, Los Angeles, California, USA.
¹¹ Intellectual and Developmental Disabilities Research Center, UCLA, Los Angeles, California, USA.

PMID: 35962745
DOI: 10.1002/epi4.12643

Abstract

The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs. In this article, we discuss CDEs for neuroimaging data that are collected in rodent models of epilepsy, with a focus on adult rats and mice. We provide detailed CDE tables and case report forms (CRFs), and with this companion manuscript, we discuss the methodologies for several imaging modalities and the parameters that can be collected.

Keywords: epilepsy; magnetic resonance imaging; magnetic resonance spectroscopy; mouse; positron emission tomography; rat; single photon emission computed tomography.