An interactive metabolic map of bio-based chemicals

Woo Dae Jang; Gi Bae Kim; Sang Yup Lee

doi:10.1016/j.tibtech.2022.07.013

An interactive metabolic map of bio-based chemicals

Trends Biotechnol. 2023 Jan;41(1):10-14. doi: 10.1016/j.tibtech.2022.07.013. Epub 2022 Aug 10.

Authors

Woo Dae Jang¹, Gi Bae Kim², Sang Yup Lee³

Affiliations

¹ Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea; Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea; BioProcess Engineering Research Center and BioInformatics Research Center, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
² Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea; Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
³ Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea; Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea; BioProcess Engineering Research Center and BioInformatics Research Center, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea. Electronic address: leesy@kaist.ac.kr.

PMID: 35961799
DOI: 10.1016/j.tibtech.2022.07.013

Abstract

Metabolic engineering for the bio-based production of chemicals requires thorough understanding of metabolic reactions including enzymes, cofactors, reactants, and products. Here we present an interactive bio-based chemicals map that visualizes compounds, enzymes, and reaction pathways together with strategies for the production of chemicals by biological, chemical, and combined methods.

Keywords: biorefinery; industrial chemicals; interactive chemicals map; metabolic engineering; natural products; sustainable production.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Metabolic Engineering*