Impact of Seasonal Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responses in Solid Organ Transplant Recipients

Andrew H Karaba; Weiqiang Zhou; Shuai Li; Tihitina Y Aytenfisu; Trevor S Johnston; Olivia Akinde; Yolanda Eby; Aura T Abedon; Jennifer L Alejo; Caroline X Qin; Elizabeth A Thompson; Jacqueline M Garonzik-Wang; Joel N Blankson; Andrea L Cox; Justin R Bailey; Sabra L Klein; Andrew Pekosz; Dorry L Segev; Aaron A R Tobian; William A Werbel

doi:10.1093/cid/ciac652

Impact of Seasonal Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responses in Solid Organ Transplant Recipients

Clin Infect Dis. 2023 Feb 8;76(3):e495-e498. doi: 10.1093/cid/ciac652.

Authors

Andrew H Karaba¹, Weiqiang Zhou², Shuai Li², Tihitina Y Aytenfisu¹, Trevor S Johnston¹, Olivia Akinde³, Yolanda Eby³, Aura T Abedon⁴, Jennifer L Alejo⁴, Caroline X Qin⁴, Elizabeth A Thompson¹, Jacqueline M Garonzik-Wang⁵, Joel N Blankson¹, Andrea L Cox^{1

6

7}, Justin R Bailey¹, Sabra L Klein⁶, Andrew Pekosz⁶, Dorry L Segev^{4

8}, Aaron A R Tobian³, William A Werbel¹

Affiliations

¹ Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
² Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
³ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁴ Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁵ Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
⁶ W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
⁷ Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁸ Department of Surgery, NYU Grossman School of Medicine, New York, New York, USA.

Abstract

Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of preexisting antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in SOTRs.

Keywords: COVID-19; SARS-CoV-2; immunocompromised hosts; vaccines.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Antibodies, Viral
COVID-19 Vaccines* / adverse effects
COVID-19* / prevention & control
Humans
Organ Transplantation* / adverse effects
SARS-CoV-2
Seasons
Transplant Recipients
Vaccination
Vaccines*

Substances

Antibodies, Viral
COVID-19 Vaccines
Vaccines

Abstract

Publication types

MeSH terms

Substances

Grants and funding