Clinical Features and Treatment Outcomes of Pulmonary Mycobacterium avium-intracellulare Complex With and Without Coinfections

Grace Wang; Jack T Stapleton; Arthur W Baker; Nadine Rouphael; C Buddy Creech; Hana M El Sahly; Jason E Stout; Lisa Jackson; Edward Charbek; Francisco J Leyva; Kay M Tomashek; Melinda Tibbals; Aaron Miller; Sharon Frey; Samson Niemotka; Timothy L Wiemken; Nour Beydoun; Ghina Alaaeddine; Nicholas Turner; Emmanuel B Walter; Robin Chamberland; Getahun Abate

doi:10.1093/ofid/ofac375

Clinical Features and Treatment Outcomes of Pulmonary Mycobacterium avium-intracellulare Complex With and Without Coinfections

Open Forum Infect Dis. 2022 Jul 26;9(8):ofac375. doi: 10.1093/ofid/ofac375. eCollection 2022 Aug.

Authors

Grace Wang¹, Jack T Stapleton², Arthur W Baker³, Nadine Rouphael⁴, C Buddy Creech⁵, Hana M El Sahly⁶, Jason E Stout³, Lisa Jackson⁷, Edward Charbek¹, Francisco J Leyva⁸, Kay M Tomashek⁸, Melinda Tibbals⁸, Aaron Miller¹, Sharon Frey¹, Samson Niemotka¹, Timothy L Wiemken¹, Nour Beydoun⁴, Ghina Alaaeddine⁴, Nicholas Turner³, Emmanuel B Walter³, Robin Chamberland⁹, Getahun Abate¹

Affiliations

¹ Department of Internal Medicine, Saint Louis University, St Louis, Missouri, USA.
² Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
³ Duke University School of Medicine, Durham, North Carolina, USA.
⁴ Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
⁵ Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
⁶ Baylor College of Medicine, Human Vaccine Institute, Houston, Texas, USA.
⁷ Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
⁸ Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
⁹ Department of Pathology, Division of Clinical Pathology, Saint Louis University School of Medicine, St Louis, Missouri, USA.

Abstract

Coinfections are more common in patients with cystic fibrosis and bronchiectasis. Infiltrates on imaging studies are seen more commonly in patients with coinfections, but coinfections did not affect treatment outcomes of pulmonary Mycobacterium avium complex.

Grants and funding

I01 BX000207/BX/BLRD VA/United States