Pouchitis: insight into the pathogenesis and clinical aspects

Leandro Minatel Vidal de Negreiros; Lívia Bitencourt Pascoal; Lívia Moreira Genaro; Julian Furtado Silva; Bruno Lima Rodrigues; Michel Gardere Camargo; Carlos Augusto Real Martinez; Cláudio Saddy Rodrigues Coy; Maria de Lourdes Setsuko Ayrizono; João José Fagundes; Raquel Franco Leal

Pouchitis: insight into the pathogenesis and clinical aspects

Am J Transl Res. 2022 Jul 15;14(7):4406-4425. eCollection 2022.

Affiliation

¹ Inflammatory Bowel Disease Research Laboratory, Colorectal Surgery Unit, Department of Surgery, School of Medical Sciences, University of Campinas (Unicamp) Campinas, Brazil.

PMID: 35958439
PMCID: PMC9360866

Abstract

Ulcerative colitis (UC) is a chronic intestinal inflammatory disease and familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease. Both diseases, despite being different, may require the same surgical procedure: proctocolectomy with ileal pouch-anal anastomosis (IPAA). The main complication after this procedure is pouch inflammation (pouchitis). This inflammatory complication can affect up to 60 percent of patients who receive IPAA for UC, and a very small percentage of the FAP patients. The purpose of this review was to determine the current molecular mechanisms in its pathogenesis and detail the risk factors involved in pouchitis, its diagnosis, and treatment.

Keywords: Ulcerative colitis; familial adenomatous polyposis; ileal pouch-anal anastomosis; pouchitis.

Publication types

Review