Spicatulides A-G, Phenolic-Monoterpenoid Hybrids from Chloranthus spicatus

J Nat Prod. 2022 Aug 26;85(8):2090-2099. doi: 10.1021/acs.jnatprod.2c00546. Epub 2022 Aug 11.

Abstract

Spicatulides A-G (1-7), seven new phenolic-monoterpenoid hybrid molecules, along with two known compounds, 8 and 9, were isolated and identified from Chloranthus spicatus. Compound 1 represents an unprecedented skeleton featuring an aryl-fused 2-oxabicyclo[4.3.1]decane moiety, and compound 2 is the first example of a denudaquinol-normonoterpenoid adduct. Their structures with absolute configurations were elucidated on the basis of spectroscopic data analyses and TDDFT-ECD calculations. Compounds 3, 5, 6, and 9 exhibited the activity of reducing lipogenesis in HepG2 cells in a dose-dependent manner.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Molecular Structure
  • Monoterpenes*
  • Seeds*

Substances

  • Monoterpenes