Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae)

Bosco Peron Leutcha; Jean Paul Dzoyem; Jean-Bosco Jouda; Denis Kehdinga Sema; Virginie Flaure Tsague Tankeu; Gabin Thierry Mbahbou Bitchagno; Billy Toussie Tchegnitegni; Flaure Rosette Ehawa Essoung; Bruno Ndjakou Lenta; Siméon Fogue Kouam; Florence Delie; Alain Meli Lannang; Norbert Sewald

doi:10.3390/molecules27154823

Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae)

Molecules. 2022 Jul 28;27(15):4823. doi: 10.3390/molecules27154823.

Authors

Bosco Peron Leutcha^{1

2}, Jean Paul Dzoyem³, Jean-Bosco Jouda⁴, Denis Kehdinga Sema¹, Virginie Flaure Tsague Tankeu¹, Gabin Thierry Mbahbou Bitchagno^{5

6}, Billy Toussie Tchegnitegni^{2

5

6}, Flaure Rosette Ehawa Essoung⁷, Bruno Ndjakou Lenta², Siméon Fogue Kouam², Florence Delie⁸, Alain Meli Lannang^{4

9}, Norbert Sewald⁶

Affiliations

¹ Department of Chemistry, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon.
² Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé P.O. Box 47, Cameroon.
³ Department of Biochemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon.
⁴ Department of Chemical Engineering, School of Chemical Engineering and Mineral Industries, University of Ngaoundere, Ngaoundéré P.O. Box 454, Cameroon.
⁵ Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon.
⁶ Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, 33501 Bielefeld, Germany.
⁷ University Institute of Technology, University of Ngaoundere, Ngaoundere P.O. Box 455, Cameroon.
⁸ Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1211 Geneva, Switzerland.
⁹ Department of Chemistry, Higher Teacher Training College, University of Maroua, Maroua P.O. Box 55, Cameroon.

Abstract

Twenty-two compounds were isolated from the fruit of Albizia lebbeck including one unprecedented, rare amino acid-derived zwitterionic and one new flavone derivative. The isolation was performed on repeated column chromatography over silica gel and their structures were determined by 1D-, 2D-NMR and HR-ESI-MS spectra together with reported data in the literature. The chemophenetic significance is also discussed. Some isolated compounds were reported for the first time to be found in the species. Additionally, compound 2 showed antibacterial activity and compounds 1 and 2 revealed moderate cytotoxic activity against the Raw 264.7 cancer cell line with IC₅₀ values of 37.19 µM and 29.36 µM, respectively. Furthermore, a proposed biosynthetic pathway of compound 1 is described.

Keywords: Acacia; Albizia lebbeck; Fabaceae; antimicrobial activity; carbamide; cytotoxicity; flavonoids.

MeSH terms

Albizzia* / chemistry
Anti-Bacterial Agents / pharmacology
Anti-Infective Agents* / pharmacology
Antineoplastic Agents* / chemistry
Fabaceae*
Fruit
Plant Extracts / chemistry
Plant Extracts / pharmacology

Substances

Anti-Bacterial Agents
Anti-Infective Agents
Antineoplastic Agents
Plant Extracts

Abstract

MeSH terms

Substances

Grants and funding