Gut-bladder axis enters the stage: Implication for recurrent urinary tract infections

Arnold M Salazar; Michael L Neugent; Nicole J De Nisco; Indira U Mysorekar

doi:10.1016/j.chom.2022.07.008

Gut-bladder axis enters the stage: Implication for recurrent urinary tract infections

Cell Host Microbe. 2022 Aug 10;30(8):1066-1069. doi: 10.1016/j.chom.2022.07.008.

Authors

Arnold M Salazar¹, Michael L Neugent², Nicole J De Nisco³, Indira U Mysorekar⁴

Affiliations

¹ Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA.
² Department of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
³ Department of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA; Department of Urology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
⁴ Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Huffington Center of Aging, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: indira.mysorekar@bcm.edu.

Abstract

The gut microbiome is a critical modulator of systemic physiology, including infectious disease susceptibility. Although this niche is a reservoir for uropathogenic Escherichia coli, knowledge of its role in urinary tract infections (UTIs) is limited. We discuss two recent studies, Thänert et al. (2022) and Worby et al. (2022), that interrogate the roles of the gut-bladder axis in UTIs.

MeSH terms

Escherichia coli Infections*
Humans
Urinary Bladder
Urinary Tract Infections*
Uropathogenic Escherichia coli*

Abstract

MeSH terms

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