A molecularly imprinted gel photonic crystal sensor for recognition of chiral amino acids

Xiuzhen Qiu; Yangyang Li; Yongbiao Hua; Dongmei Liu; Kailian Zhou; Yulin Wang; Huishi Guo

doi:10.1016/j.saa.2022.121719

A molecularly imprinted gel photonic crystal sensor for recognition of chiral amino acids

Spectrochim Acta A Mol Biomol Spectrosc. 2022 Dec 15:283:121719. doi: 10.1016/j.saa.2022.121719. Epub 2022 Aug 6.

Authors

Xiuzhen Qiu¹, Yangyang Li², Yongbiao Hua³, Dongmei Liu², Kailian Zhou², Yulin Wang², Huishi Guo⁴

Affiliations

¹ College of Chemistry and Civil Engineering, Shaoguan University, Shaoguan 512005, Guangdong, China; Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University, Shaoguan 512005, Guangdong, China. Electronic address: gold0226@126.com.
² College of Chemistry and Civil Engineering, Shaoguan University, Shaoguan 512005, Guangdong, China.
³ Department of Civil and Environmental Engineering, Hanyang University,222 Wangsimni-Ro, Seoul 04763, Korea.
⁴ College of Chemistry and Civil Engineering, Shaoguan University, Shaoguan 512005, Guangdong, China; Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University, Shaoguan 512005, Guangdong, China. Electronic address: guohuishi@163.com.

PMID: 35952590
DOI: 10.1016/j.saa.2022.121719

Abstract

A new type of photonic crystal gel molecularly imprinted sensor (MIPHs) was synthesized for the visible chiral recognition of amino acids. The color of MIPHs was changed from green to red when it exposured to various l-pyroglutamic acid concentration (0.05-1.0mmoL/L). Thanks to sensitive reflectance of photonic crystal and high selectivity of MIPs, the constructed MIPHs exhibited good performance towards l-pyroglutamic acid in terms of fast response time (3 min) and low detection limit (LOD) (2.4 μmol/L). Besides, MIPHs was found to have good selectivity toward l-pyroglutamic acid in the presence of interference group with similar structures such as d-pyroglutamic acid, l-tryptophan, l-phenylalanine, and l-proline. In light of these findings, the MIPHs can be used for highly selective recognition of l-pyroglutamic acid. It is expected that our work is able to provide a new roadmap for the chiral identification and separation of amino acids.

Keywords: Colorimetric sensor; Molecular imprinting; Photonic crystal; Pyroglutamate.

MeSH terms

Amino Acids
Molecular Imprinting*
Photons
Pyrrolidonecarboxylic Acid
Tryptophan

Substances

Amino Acids
Tryptophan
Pyrrolidonecarboxylic Acid