Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy

Nahyun Kwon; Kwang H Kim; Sinyoung Park; Yejin Cho; Eun-Yeong Park; Junha Lim; Seda Çetindere; Süreyya Oğuz Tümay; Won Jong Kim; Xingshu Li; Ki Taek Nam; Chulhong Kim; Serkan Yeşilot; Juyoung Yoon

doi:10.1016/j.bios.2022.114612

Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy

Biosens Bioelectron. 2022 Nov 15:216:114612. doi: 10.1016/j.bios.2022.114612. Epub 2022 Aug 2.

Authors

Nahyun Kwon¹, Kwang H Kim², Sinyoung Park³, Yejin Cho², Eun-Yeong Park³, Junha Lim⁴, Seda Çetindere⁵, Süreyya Oğuz Tümay⁵, Won Jong Kim⁴, Xingshu Li⁶, Ki Taek Nam⁷, Chulhong Kim⁸, Serkan Yeşilot⁹, Juyoung Yoon¹⁰

Affiliations

¹ Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 03760, Republic of Korea.
² Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
³ Departments of Electrical Engineering, Mechanical Engineering, Convergence IT Engineering, and Interdisciplinary Bioscience and Bioengineering, Graduate School of Artificial Intelligence, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
⁴ Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
⁵ Department of Chemistry, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey.
⁶ College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China. Electronic address: xingshuli@fzu.edu.cn.
⁷ Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea. Electronic address: kitaek@yuhs.ac.
⁸ Departments of Electrical Engineering, Mechanical Engineering, Convergence IT Engineering, and Interdisciplinary Bioscience and Bioengineering, Graduate School of Artificial Intelligence, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea. Electronic address: chulhong@postech.edu.
⁹ Department of Chemistry, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey. Electronic address: yesil@gtu.edu.tr.
¹⁰ Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 03760, Republic of Korea. Electronic address: jyoon@ewha.ac.kr.

PMID: 35952434
DOI: 10.1016/j.bios.2022.114612

Abstract

Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, 'safe' fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.

Keywords: Dual-modal imaging; NIR fluorescence Imaging; Photoacoustic imaging; Photothermal cancer therapy; Theragnostic nanoparticle.

MeSH terms

Animals
Biosensing Techniques*
Boron Compounds
Cell Line, Tumor
Hexosaminidase A
Mice
Nanoparticles* / chemistry
Neoplasms* / diagnostic imaging
Neoplasms* / drug therapy
Optical Imaging
Photoacoustic Techniques* / methods
Reactive Oxygen Species
Theranostic Nanomedicine / methods

Substances

4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
Boron Compounds
Reactive Oxygen Species
Hexosaminidase A