A decrease in functional microbiomes represented as Faecalibacterium affects immune homeostasis in long-term stable liver transplant patients

Gut Microbes. 2022 Jan-Dec;14(1):2102885. doi: 10.1080/19490976.2022.2102885.

Abstract

LT, liver transplantation; HCC, hepatocellular carcinoma; IS, immunosuppressants; DC, dendritic cells; Treg, regulatory T; Th17, T helper 17; AST, aspartate transaminase; ALT, alanine transaminase; OUT, operational taxonomic unit; LEfSe, linear discriminant analysis effect size; LDA, linear discriminant analysis; IL, interleukin; TGF, transforming growth factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; TNF-α, tumor necrosis factor-α; MIP-1α, macrophage inflammatory protein-1α; IP-10, interferon γ-induced protein; MCP-1, monocyte chemoattractant protein-1; ACR, acute cellular rejection; NF-κB, nuclear factor κB; PT INR, prothrombin time; QC, quality check; PBMC, peripheral blood mononuclear cells; PBS, phosphate-buffered saline; ELISA, enzyme-linked immunosorbent assay.

Keywords: Faecalibacterium; Liver transplantation; bacteroides; gut dysbiosis; gut microbiome; immunosuppressant; regulatory T cells; tolerance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Hepatocellular*
  • Cytokines
  • Faecalibacterium / metabolism
  • Gastrointestinal Microbiome*
  • Homeostasis
  • Humans
  • Leukocytes, Mononuclear / metabolism
  • Liver Neoplasms*
  • Liver Transplantation*
  • NF-kappa B
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Cytokines
  • NF-kappa B
  • Tumor Necrosis Factor-alpha