FoxP3 forkhead dimer: Don't swap me now

Indra Bekere; Carina C de Oliveira Mann

doi:10.1016/j.immuni.2022.07.012

FoxP3 forkhead dimer: Don't swap me now

Immunity. 2022 Aug 9;55(8):1329-1331. doi: 10.1016/j.immuni.2022.07.012.

Authors

Indra Bekere¹, Carina C de Oliveira Mann²

Affiliations

¹ Institute of Virology, Technical University of Munich, 81675 Munich, Germany.
² Institute of Virology, Technical University of Munich, 81675 Munich, Germany. Electronic address: carina.mann@tum.de.

PMID: 35947974
DOI: 10.1016/j.immuni.2022.07.012

Abstract

FoxP3 is critical for regulatory T cell function and, thus, overall immune homeostasis. In this issue of Immunity, Leng et al. reveal how FoxP3 achieves specific recognition of DNA and functional specialization by adopting a head-to-head domain conformation.

Publication types

Comment

MeSH terms

DNA
Forkhead Transcription Factors* / genetics
Homeostasis
T-Lymphocytes, Regulatory*

Substances

Forkhead Transcription Factors
DNA