Fluorinated organic compounds are common among pharmaceuticals, agrochemicals and materials. The significant strength of the C-F bond results in chemical inertness that, depending on the context, is beneficial, problematic or simply a formidable synthetic challenge. Electrosynthesis is a rapidly expanding methodology that can enable new reactivity and selectivity for cleavage and formation of chemical bonds. Here, a comprehensive overview of synthetically relevant electrochemically driven protocols for C-F bond activation and functionalization is presented, including photoelectrochemical strategies.