Cellular crosstalk during liver regeneration: unity in diversity

Wenzhi Shu; Mengfan Yang; Jiayin Yang; Shengda Lin; Xuyong Wei; Xiao Xu

doi:10.1186/s12964-022-00918-z

Cellular crosstalk during liver regeneration: unity in diversity

Cell Commun Signal. 2022 Aug 8;20(1):117. doi: 10.1186/s12964-022-00918-z.

Authors

Wenzhi Shu^#^{1

2

3

4

5}, Mengfan Yang^#^{1

2

3

4}, Jiayin Yang⁶, Shengda Lin^{1

7}, Xuyong Wei^{8

9

10

11}, Xiao Xu^{12

13

14

15}

Affiliations

¹ Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
² Institute of Organ Transplantation, Zhejiang University, Hangzhou, 310003, China.
³ NHC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, 310003, China.
⁴ Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, China.
⁵ Program in Clinical Medicine, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
⁶ Department of Liver Surgery and Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.
⁷ Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
⁸ Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. 1315009@zju.edu.cn.
⁹ Institute of Organ Transplantation, Zhejiang University, Hangzhou, 310003, China. 1315009@zju.edu.cn.
¹⁰ NHC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, 310003, China. 1315009@zju.edu.cn.
¹¹ Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, China. 1315009@zju.edu.cn.
¹² Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. zjxu@zju.edu.cn.
¹³ Institute of Organ Transplantation, Zhejiang University, Hangzhou, 310003, China. zjxu@zju.edu.cn.
¹⁴ NHC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, 310003, China. zjxu@zju.edu.cn.
¹⁵ Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, China. zjxu@zju.edu.cn.

^# Contributed equally.

Abstract

The liver is unique in its ability to regenerate from a wide range of injuries and diseases. Liver regeneration centers around hepatocyte proliferation and requires the coordinated actions of nonparenchymal cells, including biliary epithelial cells, liver sinusoidal endothelial cells, hepatic stellate cells and kupffer cells. Interactions among various hepatocyte and nonparenchymal cells populations constitute a sophisticated regulatory network that restores liver mass and function. In addition, there are two different ways of liver regeneration, self-replication of liver epithelial cells and transdifferentiation between liver epithelial cells. The interactions among cell populations and regenerative microenvironment in the two modes are distinct. Herein, we first review recent advances in the interactions between hepatocytes and surrounding cells and among nonparenchymal cells in the context of liver epithelial cell self-replication. Next, we discuss the crosstalk of several cell types in the context of liver epithelial transdifferentiation, which is also crucial for liver regeneration. Video abstract.

Keywords: Cellular crosstalk; Hepatocytes; Liver progenitor cells; Liver regeneration; Non-parenchymal cells.

Publication types

Review
Video-Audio Media
Research Support, Non-U.S. Gov't

MeSH terms

Endothelial Cells*
Hepatic Stellate Cells
Hepatocytes
Liver / metabolism
Liver Regeneration*