Two Laminaria japonica polysaccharides with distinct structure characterization affect gut microbiota and metabolites in hyperlipidemic mice differently

Fang Fang; Chuqiao Xiao; Chu Wan; Yaqian Li; Xingyu Lu; Ying Lin; Jie Gao

doi:10.1016/j.foodres.2022.111615

Two Laminaria japonica polysaccharides with distinct structure characterization affect gut microbiota and metabolites in hyperlipidemic mice differently

Food Res Int. 2022 Sep:159:111615. doi: 10.1016/j.foodres.2022.111615. Epub 2022 Jul 5.

Authors

Fang Fang¹, Chuqiao Xiao², Chu Wan¹, Yaqian Li¹, Xingyu Lu¹, Ying Lin³, Jie Gao⁴

Affiliations

¹ School of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China.
² Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521031, China.
³ School of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China. Electronic address: linying@gxu.edu.cn.
⁴ School of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China. Electronic address: gaojie@gxu.edu.cn.

PMID: 35940764
DOI: 10.1016/j.foodres.2022.111615

Abstract

Our previous study found dietary mannogluconic acid (MA) and fucogalactan sulfate (FS) from Laminaria japonica have distinct structure characterization and potential hypolipidemic effects in vitro. Herein, we compared the benefits of MA and FS on hyperlipidemia. The result showed only FS treatment decreased body weight and serum cholesterol levels. Compared with MA, FS was more effective in mitigating hepatic fat accumulation, promoting GSH-Px activity, reducing the MDA formation, and lowering the level of TNF-α in liver. Gut microbiota and metabolism analysis revealed that FS increased the relative abundance of beneficial bacteria and boosted the level of short chain fatty acids. Particularly, taurine and 3α,7α,12α-trihydroxy-24-oxo-5-β-cholestanoyl CoA were upregulated by FS, which might attribute to the increased Oscillibacter and thus affect the enterohepatic circulation of bile acids and serum TC level. Therefore, FS with more branches and sulfate ester groups could be a good lipid-lowering dietary supplement.

Keywords: Fucogalactan sulfate (FS); Gut microbiota; Hyperlipidemia; Mannogluconic acid (MA); Metabolome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bile Acids and Salts
Gastrointestinal Microbiome*
Laminaria* / chemistry
Mice
Polysaccharides / chemistry
Sulfates

Substances

Bile Acids and Salts
Polysaccharides
Sulfates