Targeting endoplasmic reticulum stress using natural products in neurological disorders

Ashok Jangra; Mehak Verma; Deepak Kumar; Chandrika; Mahesh Rachamalla; Abhijit Dey; Kamal Dua; Saurabh Kumar Jha; Shreesh Ojha; Athanasios Alexiou; Dinesh Kumar; Niraj Kumar Jha

doi:10.1016/j.neubiorev.2022.104818

Targeting endoplasmic reticulum stress using natural products in neurological disorders

Neurosci Biobehav Rev. 2022 Oct:141:104818. doi: 10.1016/j.neubiorev.2022.104818. Epub 2022 Aug 5.

Authors

Affiliations

¹ Department of Pharmaceutical Sciences, Central University of Haryana, Mahendergarh 123031, Haryana, India.
² Department of Biology, University of Saskatchewan,112 Science Place, Saskatoon, SK S7N 5E2, Canada.
³ Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, West Bengal, India.
⁴ Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
⁵ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No.32-34 Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, India; Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali, 140413, India; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun 248007, India.
⁶ Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates.
⁷ Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, 2770 NSW, Australia. Electronic address: alextha@yahoo.gr.
⁸ Department of Pharmaceutical Sciences, Central University of Haryana, Mahendergarh 123031, Haryana, India. Electronic address: dineshbarbola@cuh.ac.in.
⁹ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No.32-34 Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, India; Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali, 140413, India; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun 248007, India. Electronic address: nirajkumarjha2011@gmail.com.

PMID: 35940309
DOI: 10.1016/j.neubiorev.2022.104818

Abstract

The primary aim of this review is to summarize the literature on natural products that are effective in the treatment of various neurological disorders by targeting endoplasmic reticulum stress (ERS). Various electronic databases such as SCOPUS, PubMed, Web of Science, and Google Scholar were searched for relevant publications. ERS has been implicated in the pathogenesis of numerous neurological disorders such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease. Several natural products targeting ERS signalling pathways provide therapeutic options for neurological diseases, and in this review, the potential neuroprotective properties of these products are discussed.

Keywords: Alzheimer’s disease; Endoplasmic reticulum stress; Natural products; Neurodegenerative diseases; Neurological disorders; Neuroprotection; Neuroprotective agents; Parkinson’s disease.

Publication types

Review

MeSH terms

Alzheimer Disease* / drug therapy
Biological Products* / pharmacology
Biological Products* / therapeutic use
Endoplasmic Reticulum Stress
Humans
Nervous System Diseases* / drug therapy
Neuroprotective Agents* / pharmacology
Neuroprotective Agents* / therapeutic use
Parkinson Disease* / drug therapy

Substances

Biological Products
Neuroprotective Agents