Electrokinetics in antimicrobial resistance analysis: A review

Electrophoresis. 2023 Jan;44(1-2):323-336. doi: 10.1002/elps.202200153. Epub 2022 Sep 2.

Abstract

Infections caused by antimicrobial resistance are a serious problem in the world. Currently, commercial devices for antimicrobial susceptibility testing and resistant bacteria identification are time-consuming. There is an urgent need to develop fast and accurate methods, especially in the process of sample pretreatment. Electrokinetic (EK) is a family of electric-field-based kinetic phenomena of fluid or embedded objects, and EK applications have been found in various fields. In this paper, EK bacteria manipulation, including enrichment and separation, is reviewed. Focus is given to the rapid electric-based minimum inhibitory concentration measurement. The future directions and major challenges in this field are also outlined.

Keywords: antimicrobial susceptibility testing; bacteria; electrokinetics; manipulation.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Bacteria
  • Drug Resistance, Bacterial*
  • Electricity
  • Kinetics

Substances

  • Anti-Bacterial Agents