[Proliferative activity of endotheliocytes of growing corneal capillaries in the rabbit]

Biull Eksp Biol Med. 1987 May;103(5):613-7.
[Article in Russian]

Abstract

The intensity of capillaries growth in the rabbit's cornea was investigated after chemical burn and exposure to colchicine. Proliferative activity was determined in endothelial cells along the course of newly formed capillaries. Growth intensity proved to be 2 times higher when burn and colchicine effects were combined, than in case of burn alone. The increase in the proliferative activity of endothelial cells and the peculiarities of their arrangement were found in both cases. The most active proliferation was observed in cells located in a zone where capillaries originated from intact vessels of the limb. The process of new vessel formation depends on endotheliocyte shift from this zone towards the site where growth-stimulating factors were applied.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Burns, Chemical / metabolism
  • Burns, Chemical / pathology
  • Capillaries / cytology
  • Capillaries / drug effects
  • Capillaries / growth & development
  • Cell Division / drug effects
  • Colchicine / pharmacology
  • Cornea / blood supply*
  • Cornea / drug effects
  • Corneal Injuries
  • DNA / biosynthesis
  • Endothelium / cytology
  • Endothelium / drug effects
  • Eye Burns / chemically induced
  • Eye Burns / metabolism
  • Eye Burns / pathology
  • Rabbits
  • Silver Nitrate / toxicity

Substances

  • DNA
  • Silver Nitrate
  • Colchicine