Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis

Hui-Ming Chen; Hang Li; Meng-Xian Lin; Wei-Jie Fan; Yi Zhang; Yan-Ting Lin; Shu-Xiang Wu

doi:10.3389/fgene.2022.952667

Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis

Front Genet. 2022 Jul 22:13:952667. doi: 10.3389/fgene.2022.952667. eCollection 2022.

Authors

Hui-Ming Chen^{1

2}, Hang Li¹, Meng-Xian Lin¹, Wei-Jie Fan¹, Yi Zhang¹, Yan-Ting Lin^{1

2}, Shu-Xiang Wu^{1

2}

Affiliations

¹ Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
² Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China.

Abstract

As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate. As high-throughput sequencing and antibody technologies advanced by leaps and bounds, the association of RNA modifications with multiple human diseases sparked research enthusiasm; in addition, aberrant RNA modification leads to tumor angiogenesis by regulating angiogenesis-related factors. This review collected recent cutting-edge studies focused on RNA modifications (N⁶-methyladenosine (m⁶A), N⁵-methylcytosine (m⁵C), N⁷-methylguanosine (m⁷G), N¹-methyladenosine (m¹A), and pseudopuridine (Ψ)), and their related regulators in tumor angiogenesis to emphasize the role and impact of RNA modifications.

Keywords: RNA modifications; angiogenesis; m5C; m6A; tumor.

Publication types

Review