Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults

Adrián Montes-de-Oca-García; Juan Corral-Pérez; Daniel Velázquez-Díaz; Alejandro Perez-Bey; María Rebollo-Ramos; Alberto Marín-Galindo; Félix Gómez-Gallego; Maria Calderon-Dominguez; Cristina Casals; Jesús G Ponce-González

doi:10.3389/fphys.2022.885185

Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults

Front Physiol. 2022 Jul 22:13:885185. doi: 10.3389/fphys.2022.885185. eCollection 2022.

Authors

Adrián Montes-de-Oca-García^{1

2}, Juan Corral-Pérez^{1

2}, Daniel Velázquez-Díaz^{1

2

3}, Alejandro Perez-Bey^{2

4}, María Rebollo-Ramos^{1

2}, Alberto Marín-Galindo^{1

2}, Félix Gómez-Gallego⁵, Maria Calderon-Dominguez^{2

6}, Cristina Casals^{1

2}, Jesús G Ponce-González^{1

2}

Affiliations

¹ MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cádiz, Spain.
² Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain.
³ Department of Psychology, Brain Aging and Cognitive Health Laboratory, University of Pittsburgh, Pittsburgh, PA, United States.
⁴ Department of Physical Education, GALENO Research Group, Faculty of Education Sciences, University of Cadiz, Cádiz, Spain.
⁵ Faculty of Health Sciences, International University of La Rioja, Logroño, Spain.
⁶ Biomedicine, Biotechnology and Public Health Department, University of Cadiz, Cádiz, Spain.

Abstract

This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C>T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 ± 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C>T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p < 0.001). The recessive model (CC vs. CT/TT) showed similar results but also with differences in basal metabolism (p = 0.045) and total energy expenditure (p = 0.024). A genotype*sex interaction was found in the QUICKI index (p = 0.016), with differences between CC and CT/TT in men (p = 0.049) and between men and women inside the CT/TT group (p = 0.049). Thus, the PPARGC1A gene rs8192678 C>T polymorphism is associated with body composition, basal metabolism, total energy expenditure, and BP recovery, where the CC genotype confers a protective effect. Moreover, our study highlighted sexual dimorphism in the influence of PPARGC1A gene rs8192678 C>T polymorphism on the QUICKI index.

Keywords: PPARGC1A; cardiometabolic risk; caucasian; genetic association studies; healthy lifestyle; metabolism; obesity; physical exercise.