The regulation of yes-associated protein/transcriptional coactivator with PDZ-binding motif and their roles in vascular endothelium

Wen Zhang; Qian-Qian Li; Han-Yi Gao; Yong-Chun Wang; Min Cheng; Yan-Xia Wang

doi:10.3389/fcvm.2022.925254

The regulation of yes-associated protein/transcriptional coactivator with PDZ-binding motif and their roles in vascular endothelium

Front Cardiovasc Med. 2022 Jul 22:9:925254. doi: 10.3389/fcvm.2022.925254. eCollection 2022.

Authors

Wen Zhang¹, Qian-Qian Li¹, Han-Yi Gao², Yong-Chun Wang³, Min Cheng⁴, Yan-Xia Wang¹

Affiliations

¹ School of Rehabilitation Medicine, Weifang Medical University, Weifang, China.
² Department of Rehabilitation Medicine, Affiliated Hospital, Weifang Medical University, Weifang, China.
³ The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
⁴ School of Basic Medicine, Weifang Medical University, Weifang, China.

Abstract

Normal endothelial function plays a pivotal role in maintaining cardiovascular homeostasis, while endothelial dysfunction causes the occurrence and development of cardiovascular diseases. Yes-associated protein (YAP) and its homolog transcriptional co-activator with PDZ-binding motif (TAZ) serve as crucial nuclear effectors in the Hippo signaling pathway, which are regulated by mechanical stress, extracellular matrix stiffness, drugs, and other factors. Increasing evidence supports that YAP/TAZ play an important role in the regulation of endothelial-related functions, including oxidative stress, inflammation, and angiogenesis. Herein, we systematically review the factors affecting YAP/TAZ, downstream target genes regulated by YAP/TAZ and the roles of YAP/TAZ in regulating endothelial functions, in order to provide novel potential targets and effective approaches to prevent and treat cardiovascular diseases.

Keywords: YAP/TAZ; angiogenesis; endothelial cells; inflammation; oxidative stress.

Publication types

Review