Mathematical modeling of intercellular interactions within the biofilm

Ao Xia; Huize Chen; Yun Huang; Xun Zhu; Qiang Liao

doi:10.1016/j.tim.2022.07.005

Mathematical modeling of intercellular interactions within the biofilm

Trends Microbiol. 2022 Oct;30(10):925-929. doi: 10.1016/j.tim.2022.07.005. Epub 2022 Aug 4.

Authors

Ao Xia¹, Huize Chen², Yun Huang², Xun Zhu², Qiang Liao³

Affiliations

¹ Key Laboratory of Low-grade Energy Utilization Technologies and Systems, Chongqing University, Ministry of Education, Chongqing 400044, PR China; Institute of Engineering Thermophysics, School of Energy and Power Engineering, Chongqing University, Chongqing 400044, PR China. Electronic address: aoxia@cqu.edu.cn.
² Key Laboratory of Low-grade Energy Utilization Technologies and Systems, Chongqing University, Ministry of Education, Chongqing 400044, PR China; Institute of Engineering Thermophysics, School of Energy and Power Engineering, Chongqing University, Chongqing 400044, PR China.
³ Key Laboratory of Low-grade Energy Utilization Technologies and Systems, Chongqing University, Ministry of Education, Chongqing 400044, PR China; Institute of Engineering Thermophysics, School of Energy and Power Engineering, Chongqing University, Chongqing 400044, PR China. Electronic address: lqzx@cqu.edu.cn.

PMID: 35934630
DOI: 10.1016/j.tim.2022.07.005

Abstract

Bacteria accumulate and are embedded in a self-produced matrix, forming the biofilm. The interactions among cells drive the development of biofilms and provide properties that differ from planktonic cells. This forum article focuses on how intercellular mechanical interactions and physiological behaviors lead to community-scale features via exploring the applicability of biofilm mathematical models.

Keywords: biofilm; individual-based model; intercellular interactions; modeling; structure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacteria* / genetics
Biofilms*
Models, Theoretical