Advances in microbial production of feed amino acid

Kuo Zhao; Jianmin Liu; Cong Gao; Jia Liu; Xiulai Chen; Liming Liu; Liang Guo

doi:10.1016/bs.aambs.2022.05.001

Advances in microbial production of feed amino acid

Adv Appl Microbiol. 2022:119:1-33. doi: 10.1016/bs.aambs.2022.05.001. Epub 2022 Jun 10.

Authors

Kuo Zhao¹, Jianmin Liu², Cong Gao¹, Jia Liu¹, Xiulai Chen¹, Liming Liu¹, Liang Guo³

Affiliations

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, China.
² Shandong Huishilai Biotechnology Co., Ltd, Jinan, China.
³ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, China. Electronic address: liangguo@jiangnan.edu.cn.

PMID: 35933116
DOI: 10.1016/bs.aambs.2022.05.001

Abstract

Feed amino acids have numerous applications, and the market demand for them is likely to grow. Microbial cell factories promise the sustainable production of feed amino acids; however, their performance is significantly affected by the availability of precursors, carbon metabolic flux, and transporter systems. To circumvent these potential roadblocks, high-performance microbial cell factories have been constructed by strengthening the supply of precursors, increasing metabolic pathway flux, and engineering transporters. In this review, limiting factors and recent technical advances affecting the production of feed amino acids in microbial cell factories are discussed. In addition, existing challenges and potential strategies for increasing the output of these amino acids are described.

Keywords: Feed amino acid; Metabolic pathway flux; Microbial cell factory; Supply of precursors; Transporter engineering.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids*
Metabolic Engineering*
Metabolic Networks and Pathways

Substances

Amino Acids