The expanding role of BAP1 in clear cell renal cell carcinoma

Hum Pathol. 2023 Mar:133:22-31. doi: 10.1016/j.humpath.2022.07.022. Epub 2022 Aug 4.

Abstract

Mutations drive renal cell carcinoma biology and tumor growth. The BRCA1-associated protein-1 (BAP1) gene is frequently mutated in clear cell renal cell carcinoma (ccRCC) and has emerged as a prognostic and putative predictive biomarker. In this review, we discuss the role of BAP1 as a signature event of a subtype of ccRCC marked by aggressiveness, inflammation, and possibly a heightened response to immunotherapy.

Keywords: BAP1; PBRM1; RCC; ccRCC.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biomarkers, Tumor / genetics
  • Carcinoma, Renal Cell* / genetics
  • Carcinoma, Renal Cell* / pathology
  • DNA-Binding Proteins / genetics
  • Humans
  • Kidney Neoplasms* / genetics
  • Kidney Neoplasms* / pathology
  • Mutation
  • Transcription Factors / genetics
  • Tumor Suppressor Proteins* / genetics
  • Ubiquitin Thiolesterase / genetics

Substances

  • BAP1 protein, human
  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • Transcription Factors
  • Tumor Suppressor Proteins
  • Ubiquitin Thiolesterase