Integrated meta-analysis, data mining, and animal experiments to investigate the efficacy and potential pharmacological mechanism of a TCM tonic prescription, Jianpi Tongmai formula, in depression

Dan Xue; Yuhui Zhang; Zhujin Song; Xiao Jie; Ruiting Jia; Aisong Zhu

doi:10.1016/j.phymed.2022.154344

Integrated meta-analysis, data mining, and animal experiments to investigate the efficacy and potential pharmacological mechanism of a TCM tonic prescription, Jianpi Tongmai formula, in depression

Phytomedicine. 2022 Oct:105:154344. doi: 10.1016/j.phymed.2022.154344. Epub 2022 Jul 22.

Authors

Dan Xue¹, Yuhui Zhang¹, Zhujin Song¹, Xiao Jie¹, Ruiting Jia¹, Aisong Zhu²

Affiliations

¹ College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China; Key Labortary of Blood-stasis-toxin Syndrome of Zhejiang Province, Hangzhou 310053, China.
² College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China; Key Labortary of Blood-stasis-toxin Syndrome of Zhejiang Province, Hangzhou 310053, China; Zhejiang Engineering Research Center for "Preventive Treatment" Smart Health of Traditional Chinese Medicine, Hangzhou 310053, China. Electronic address: liaoningzhongyi@hotmail.com.

PMID: 35932605
DOI: 10.1016/j.phymed.2022.154344

Abstract

Background: Depression is a common psychiatric disorder and has become a growing public health issue. Traditional Chinese medicine (TCM) tonic prescriptions have been clinically proven to be an effective treatment for depression.

Purpose: This study aimed to identify the core prescription to improve depression among the numerous TCM tonic prescriptions.

Methods and results: First, we used meta-analysis to clarify the efficacy and safety of tonic prescriptions in depression among 37 studies and identified 16 effective tonic prescriptions. Second, we conducted data mining to analyze the tonic prescriptions and identified important nourishing herbs. Third, based on the data mining results, we constructed a Delphi experiment to investigate the effects of these important nourishing herbs in depression. Combining the results of Delphi expert questionnaires and weight analysis, a core TCM tonic prescription, Jianpi Tongmai formula (JPTMF) for the treatment of depression, was constructed and was composed of invigorating Spleen qi herbs. Fourth, we verified that JPTMF can improve chronic unpredictable mild stress (CUMS) induced depression-like behaviors in mice. Fifth, we predicted that the mechanism of JPTMF in the treatment of depression was mainly associated with chemical synaptic transmission and neuroinflammation through network pharmacology and determined preliminary confirmation through animal experiments.

Conclusion: This study was undertaken to evaluate the efficacy of TCM tonic prescriptions on depression and construct a core TCM tonic prescription, JPTMF, through a progressive analysis. Network pharmacology and animal experiments verified the reliability of JPTMF. The proposal of JPTMF is of innovative significance, and may provide far-reaching implications for improving depression by using nourishing herbs. Furthermore, the integrated methods applied in this study provide an innovative paradigm for the standardization and scientific basis of TCM research.

Keywords: Data mining; Depression; Integrated method; Meta-analysis; Network pharmacology; Tonic TCM prescription.

Publication types

Meta-Analysis

MeSH terms

Animal Experimentation*
Animals
Data Analysis
Data Mining
Depression
Drugs, Chinese Herbal*
Humans
Medicine, Chinese Traditional
Mice
Prescriptions
Reproducibility of Results

Substances

Drugs, Chinese Herbal
tongmai formula