Seroprevalence of anti-myelin oligodendrocyte glycoprotein antibodies in adults with myelitis

Ann Clin Transl Neurol. 2022 Sep;9(9):1481-1486. doi: 10.1002/acn3.51642. Epub 2022 Aug 6.

Abstract

Although myelitis is the second most common presentation in adults with myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD), studies on MOG-IgG seroprevalence in patients with myelitis episodes are sparse. Herein, we investigated MOG-IgG seroprevalence in Korean adults who exhibited myelitis since 2017. Among 151 adults with acute myelitis, 11 (7.3%) tested positive for MOG-IgG by the initial screening and 10 (6.6%) patients were finally diagnosed with MOGAD during the study period. This study is the first to provide data on MOG-IgG seroprevalence in adults with myelitis and supports the clinical utility and importance of MOG-IgG testing in myelitis episodes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Immunoglobulin G
  • Myelin-Oligodendrocyte Glycoprotein
  • Myelitis* / epidemiology
  • Oligodendroglia
  • Seroepidemiologic Studies

Substances

  • Immunoglobulin G
  • Myelin-Oligodendrocyte Glycoprotein

Grants and funding

This work was funded by National Research Foundation of Korea grant NRF‐2018R1A5A2023127.