Human colonic catabolism of dietary flavan-3-ol bioactives

Giuseppe Di Pede; Pedro Mena; Letizia Bresciani; Tahani M Almutairi; Daniele Del Rio; Michael N Clifford; Alan Crozier

doi:10.1016/j.mam.2022.101107

Human colonic catabolism of dietary flavan-3-ol bioactives

Mol Aspects Med. 2023 Feb:89:101107. doi: 10.1016/j.mam.2022.101107. Epub 2022 Aug 2.

Authors

Giuseppe Di Pede¹, Pedro Mena², Letizia Bresciani¹, Tahani M Almutairi³, Daniele Del Rio², Michael N Clifford⁴, Alan Crozier⁵

Affiliations

¹ Human Nutrition Unit, Department of Food and Drug, University of Parma, 43125, Parma, Italy.
² Human Nutrition Unit, Department of Food and Drug, University of Parma, 43125, Parma, Italy; Microbiome Research Hub, University of Parma, 43124, Parma, Italy.
³ Department of Chemistry, King Saud University, Riyadh, 11363, Saudi Arabia.
⁴ School of Bioscience and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK; Department of Nutrition, Dietetics, and Food, School of Clinical Sciences at Monash Health, Faculty of Medicine Nursing and Health Sciences, Monash University, Notting Hill, Victoria, 3168, Australia.
⁵ Department of Chemistry, King Saud University, Riyadh, 11363, Saudi Arabia; School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, G12 8QQ, United Kingdom. Electronic address: alan.crozier44@gmail.com.

PMID: 35931563
DOI: 10.1016/j.mam.2022.101107

Abstract

Understanding the fate of ingested polyphenols is crucial in elucidating the molecular mechanisms underlying the beneficial effects of a fruit and vegetable-based diet. This review focuses on the colon microbiota-mediated transformation of the flavan-3-ols and the structurally related procyanidins found in dietary plant foods and beverages, plus the flavan-3-ol-derived theaflavins of black tea, and the post-absorption phase II metabolism of the gut microbiota catabolites. Despite significant advances in the last decade major analytical challenges remain. Strategies to address them are presented.

Keywords: Colonic catabolic and phase II metabolism; Flavan-3-ols; Procyanidins; Theaflavins; [2–(14)C](−)-Epicatechin.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Colon / metabolism
Diet
Flavonoids* / metabolism
Humans
Polyphenols* / metabolism

Substances

flavan-3-ol
Flavonoids
Polyphenols