Stress and the CITI

Mol Cell. 2022 Aug 4;82(15):2730-2731. doi: 10.1016/j.molcel.2022.07.002.

Abstract

Transcription-coupled cellular stress is associated with several physiological and pathological features, including membraneless biomolecular condensates. In the study by Yasuhara et al., the authors have described specific nuclear condensates in multiple cell types upon inhibition of RNA polymerase II transcription, discovered their main constituent proteins, and elucidated their functions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Organelles* / metabolism
  • Proteins* / metabolism
  • RNA Polymerase II / genetics
  • RNA Polymerase II / metabolism

Substances

  • Proteins
  • RNA Polymerase II