Nature contributes substantially to human well-being through its diverse material and nonmaterial contributions. However, despite the growing literature on the nonmaterial dimensions of human-nature relations, we lack a systematic understanding of how they are linked with human well-being. Here, we use the concept of cultural ecosystem services (CESs) as a lens to explore this interface. Through a systematic review of the peer-reviewed literature, we elicit the unique pathways and mechanisms linking individual CESs and constituents of human well-being, as well as their relative effects. Subsequently, we identify their complex interactions through latent class analysis and multiple correspondence analysis, which delineate five major assemblages that reflect synergies and trade-offs at the interface of CESs and human well-being. We critically discuss key research trends and gaps and propose directions for future research and practice to leverage the potential of the nonmaterial contributions of nature for human well-being and sustainability more broadly.