Three new long-chain polyenes from the mangrove-derived fungus Penicillium herquei JX4

Kai-Yuan Long; De-Cai Dai; Cai-Juan Zheng; Yi-Tong Wang; Xin-Ming Song; Xuan Chen; Xue-Ming Zhou; Guang-Ying Chen

doi:10.1080/10286020.2022.2104718

Three new long-chain polyenes from the mangrove-derived fungus Penicillium herquei JX4

J Asian Nat Prod Res. 2023 May;25(5):422-428. doi: 10.1080/10286020.2022.2104718. Epub 2022 Aug 5.

Authors

Kai-Yuan Long^{1

2}, De-Cai Dai^{1

3}, Cai-Juan Zheng^{1

2}, Yi-Tong Wang^{1

2}, Xin-Ming Song^{1

2}, Xuan Chen^{1

2}, Xue-Ming Zhou^{1

2}, Guang-Ying Chen^{1

2}

Affiliations

¹ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry & Chemical Engineering, Hainan Normal University, Haikou 571158, China.
² Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
³ Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, Hainan Vocational University of Science and Technology, Haikou 571126, China.

PMID: 35930272
DOI: 10.1080/10286020.2022.2104718

Abstract

One new epimer pair of long-chain polyenes penicilqueis E (1) and F (2), and one new long-chain polyene pinophol G (3), along with one known compound (4), were obtained from EtOAc extract of the mangrove-derived fungus Penicillium herquei JX4. Their structures were elucidated by detailed analysis of comprehensive spectroscopic data. The inhibitory activities of all compounds against the nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro were evaluated.

Keywords: Penicillium herquei; anti-inflammatory activity; long-chain polyenes.

MeSH terms

Animals
Mice
Molecular Structure
Penicillium* / chemistry
Polyenes*
RAW 264.7 Cells

Substances

Polyenes

Supplementary concepts

Penicillium herquei